Table 2 Univariate and multivariate analysis of the relationship between circTADA2As expression (2−ΔΔCt) and DFS or OS in TNBC

From: circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis

Variable

DFS

OS

 

Samples

Univariate analysis

Multivariate analysis (N = 99)

Samples

Univariate analysis

Multivariate analysis (N = 99)

  

HR

95% CI

p value

HR

95% CI

p value

 

HR

95% CI

p value

HR

95% CI

p value

Age (<50 /≥50)

107

0.81

0.304–2.157

0.673

   

107

1.291

0.459–3.634

0.629

   

AJCC TNM stage (III–IV/I–II)a

104

6.188

2.243–17.07

0.000**

   

104

5.301

1.882–14.928

0.002**

   

T classification (T3–4/T1–2)b

99

3.726

1.037–13.384

0.044*

4.153

1.125–15.335

0.033*

99

6.616

1.987–22.032

0.002**

11.515

2.908–45.593

0.001**

Lymphatic metastasis (N2–3/N0–1)

107

6.627

2.458–17.866

0.000**

5.261

1.817–15.228

0.002**

107

5.640

2.038–15.610

0.001**

4.94

1.531–15.916

0.008**

circTADA2A-E6

107

  

0.031*

   

107

  

0.018*

  

0.057*

 High

25

      

25

      

 Medium

21

10.585

1.299–86.267

0.028*

   

21

11.426

1.4–93.227

0.023*

8.365

0.938–74.599

0.057

 Low

61

3.811

0.476–30.481

0.207

   

61

3.497

0.429–28.486

0.106

2.34

0.279–19.644

0.434

circTADA2A-E5/E6

107

  

0.424

   

107

  

0.394

   

 High

16

      

16

      

 Medium

31

2.437

0.272–21.823

0.426

   

32

3.877

0.465–32.330

0.211

   

 Low

60

3.575

0.461–27.715

0.223

   

59

2.372

0.295–19.065

0.416

   
  1. AJCC American Joint Committee on Cancer
  2. *p < 0.05
  3. **p < 0.01
  4. a2.8% patient information missing
  5. b7.48% patient information missing
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