Fig. 2: Loss of the FasL/Fas signaling exacerbates cell death and compensatory proliferation in NEMOΔhepa mice. | Cell Death & Disease

Fig. 2: Loss of the FasL/Fas signaling exacerbates cell death and compensatory proliferation in NEMOΔhepa mice.

From: Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease

Fig. 2

a Representative TUNEL staining of 8-week-old NEMOf/f, NEMOΔhepa, Faslpr, and NEMOΔhepa/Faslpr livers. b TUNEL-positive cells were quantified and graphed. c Proliferation was determination by Ki-67-positive cells immunofluorescence. d Ki-67-positive cells were quantified and graphed. e Expression of PCNA, cleaved Caspase-3 (CC3), and RIPK1 was analysed by immunoblotting of whole liver extracts. GAPDH served as a loading control. Results are expressed as mean ± SEM (n = 8 livers, p < 0.001–0.05)

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