Fig. 3: Loss of Fas attenuates liver fibrogenesis in NEMOΔhepa livers. | Cell Death & Disease

Fig. 3: Loss of Fas attenuates liver fibrogenesis in NEMOΔhepa livers.

From: Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease

Fig. 3

a Sirius red staining of paraffin-embedded liver tissue derived from 8-week-old livers of NEMOf/f, NEMOΔhepa, Faslpr, and NEMOΔhepa/Faslpr mice. Representative photomicrographs taken under polarized light are shown. SR-positive area was quantifed using ImageJ© and represented. MRNA relative expression of b Collagen-1A1, c Mmp2, and d Timp1 was quantified by RT-PCR. e Percentage of F4/80hiCD11hi-positive cells of each mouse strain was assessed using FACS analysis. Results are expressed as mean ± SEM (n = 8, p < 0.001–0.01)

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