Fig. 5: Deletion of TNFR1 amplifies the protective effect of Fas signalling blockade in NEMO mice. | Cell Death & Disease

Fig. 5: Deletion of TNFR1 amplifies the protective effect of Fas signalling blockade in NEMO mice.

From: Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease

Fig. 5

Faslpr/TNFR1−/− and NEMOΔhepa/Faslpr/TNFR1−/− mice at the age of 12 months were sacrificed and livers extracted and analyzed. a Macroscopic appearance of livers. Arrows show visible nodules. The number of nodules (≥5 mm) diameter was quantified. b Representative H&E staining of liver sections. Liver weight versus body weight (LW/BW) ratio is shown. Serum AST (c) and AP (d) were determined in the same mice and compared to 1-year-old NEMOf/f, NEMOΔhepa, Faslpr, and NEMOΔhepa/Faslpr. e Sirius red staining of paraffin-embedded liver tissue was performed and photomicrographs were taking. SR-positive area was quantifed using ImageJ© and represented including 1-year-old NEMOf/f, NEMOΔhepa, Faslpr, and NEMOΔhepa/Faslpr. Results are expressed as mean ± SEM (n = 25, *p < 0.05; **p < 0.01)

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