Table 1 List of the 30 genes with the most important modification of expression after TGFβ and TNFα treatment
From: EMT is associated with an epigenetic signature of ECM remodeling genes
Gene | p Value | Up/down | Fold | Protein type/RNA | Pathways |
|---|---|---|---|---|---|
CCL5 | 4.2E−9 | Up | 131.8 | Chemokine | Immunoregulation |
IL7R | 9.7E−10 | Up | 149.4 | Interleulin receptor | Immunoregulation |
MMP1 | 3.5E-1 | Up | 126 | Matrix metallopeptidase | Invasion |
MMP9 | 2.2E−4 | Up | 114.1 | Matrix metallopeptidase | Invasion |
C4orf26 | 1.0E−4 | Up | 100.1 | Extracellular protein | Mineralization |
UBD | 1.4E−5 | Up | 105.8 | Ubuiquitin | Protein ubiquitination/TNF pathway |
LCE3D | 0.0039 | Up | 99.2 | Late cornified envelope | Keratinization/development |
INHBA | 0.0040 | Up | 82.6 | FSH secretion inhibitor | Growth/differentiation factor |
CSF2 | 0.0070 | Up | 66.5 | Cytokine | Immunoregulation |
SLAMF8 | 3.9E−6 | Up | 60.4 | Cell surface receptor | Immunoregulation |
ROBO4 | 2.0E−7 | Up | 62.4 | Cell surface receptor | Angiogenesis/migration |
MROH3P | 1.5E−6 | Up | 40.0 | pseudogene | |
CDH1 | 0.0011 | Down | 40.8 | Cadherin | Cell adhesion |
MMP10 | 1.5E−5 | Up | 42.6 | Metalloprotease | Invasion/metastasis |
FAP | 0.00389 | Up | 45.1 | Cell surface protein | Invasion/immunoregulation/tumor growth |
lnc-C15orf48–1 | 1.9E−6 | Up | 45.2 | Non-coding RNA | |
C15orf48 | 0.0012 | Up | 47.0 | Metabolism | |
lnc-LRRC1–5 | 1.3E−5 | Up | 47.7 | Non-coding RNA | |
LAMC2 | 2.1E−5 | Up | 47.8 | Extracellular protein | Adhesion/differentiation/migration/metastasis |
FGFBP1 | 0.0014 | Down | 48.3 | Extracellular protein | Cell proliferation/diffentiation/migration |
NLRP3 | 0.0039 | Up | 30.9 | Cell signaling | Inflammation/apoptosis |
BMP2 | 0.0013 | Up | 33.6 | Cytokine | Differentiation |
KANK4 | 0.0060 | Up | 34.0 | Cell signaling | Cytoskeleton remodeling |
ADAMTS6 | 9.3E−5 | Up | 34.2 | Metallopeptidase | Migration/Invasion |
DHRS2 | 2.0E−6 | Up | 38.9 | Dehydrogenase/reductase | |
DCN | 7.0E−5 | Up | 39.7 | Proteoglycan | Migration /TGFb signaling |
LCE3E | 0.0016 | Up | 29.8 | Late cornified envelope | Keratinization/development |
CXCL8 | 7.3E−5 | Up | 29.6 | Chemokine | Inflammation |
LINC01583 | 6.2E−6 | Up | 28.1 | Non-coding RNA | |
ADAM19 | 9.3E−7 | Up | 27.4 | Metallopeptidase | Adhesion |
