Table 2 Expression of genes related to EMT after TGFβ and TNFα treatment
From: EMT is associated with an epigenetic signature of ECM remodeling genes
Gene | Protein | Cells | p Value | Up/down | Fold | Marker |
|---|---|---|---|---|---|---|
CDH1 | E-CADHERIN | A549 | 1.6E−6 | Down | 250 | Epithelial |
ACHN | 0.007 | Down | 105 | |||
MCF10A | 8.1E−4 | Down | 2.6 | |||
EPCAM | EPCAM | A549 | 0.001 | Down | 14 | Epithelial |
ACHN | 0.001 | Down | 2.8 | |||
MCF10A | 1.7E−4 | Down | 32 | |||
CDH2 | N-CADHERIN | A549 | 3.9E−4 | Up | 5.2 | Mesenchymal |
ACHN | 0.001 | Up | 2.0 | |||
MCF10A | 1.8E−4 | Up | 6.3 | |||
VIM | VIMENTIN | A549 | 0.003 | Up | 2.0 | Mesenchymal |
ACHN | — | |||||
MCF10A | — | |||||
ZEB1 | ZEB1 | A549 | 1.6E−4 | Up | 2.6 | EMT-ATF |
ACHN | — | |||||
MCF10A | 0.001 | Up | 3.8 | |||
ZEB2 | ZEB1 | A549 | 6.3E−4 | Up | 2.8 | EMT-ATF |
ACHN | — | |||||
MCF10A | 0,001 | Up | 2.8 | |||
SNAI1 | SNAIL1 | A549 | 3.1E−5 | Up | 2.8 | EMT-ATF |
ACHN | — | |||||
MCF10A | 2.0E-4 | Up | 7.0 | |||
A549 | 0.0010 | Down | 2.4 | Epithelial | ||
OCLN | OCCUDIN | ACHN | — | |||
MCF10A | — | |||||
ETS1 | ETS1 | A549 | 2.1E−5 | Up | 3.2 | Mesenchymal |
ACHN | 0.0024 | Up | 2.5 | |||
MCF10A | 2.7E−5 | Up | 11.85 | |||
FN1 | FIBRONECTIN | A549 | 2.2E−4 | Up | 11.7 | Mesenchymal |
ACHN | — | |||||
MCF10A | 0.0091 | Up | 68.4 | |||
SDC1 | SYNDECAN-1 | A549 | 3.0E−5 | Up | 2.8 | Mesenchymal |
ACHN | — | |||||
MCF10A | — | |||||
SNAI2 | SLUG | A549 | 3.5E−6 | Up | 17.6 | EMT-ATF |
ACHN | — | |||||
MCF10A | — |
