Fig. 8: Effects of sphingosine-1-phosphate receptor 1 (S1PR1) on tumor growth and vasculogenic mimicry (VM) in vivo. | Cell Death & Disease

Fig. 8: Effects of sphingosine-1-phosphate receptor 1 (S1PR1) on tumor growth and vasculogenic mimicry (VM) in vivo.

From: S1PR1 regulates the switch of two angiogenic modes by VE-cadherin phosphorylation in breast cancer

Fig. 8

a Tumor growth curves showed that tumor growth in the S1PR1 overexpression groups was slower than that in the control, whereas tumor growth in the S1PR1 downregulation groups was faster than that in the control. b The numbers of VM tubules and the number of EVD per 40 × field of view. c VM (red arrow) and endothelium-dependent vessels (EDVs; black arrow) channels with or without red blood cells revealed by endomucin/PAS double-staining (400 × , bar 50 µm). The S1PR1, VE-cadherin, and β-catenin expression levels were evaluated by IHC staining (400 × ). *p < 0.05

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