Fig. 1: Lobaplatin inhibits cell growth and induces cell pyroptosis in colon cancer cells. | Cell Death & Disease

Fig. 1: Lobaplatin inhibits cell growth and induces cell pyroptosis in colon cancer cells.

From: Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

Fig. 1

HT-29 and HCT116 cells were treated with different doses (0, 8, 16 and 32 μg/ml) of lobaplatin for 8 h. Cell viability was then determined using the CCK8 assay (a). Representative bright-field (b, c) and transmission electron microscopy (d, e) images of HT-29 and HCT116 cells treated with 16 μg/ml lobaplatin for 8 h. Red arrowheads indicate the large bubbles emerging from the plasma membrane. Scale bar 50 μm. The release of LDH and IL-1β from lobaplatin-treated HT-29 and HCT116 cells was measured by ELISA (f). All the data are presented as the mean ± SD from three independent experiments. *p < 0.05 vs. control using one-way ANOVA

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