Table 1 Selected neuronal proteins with at least one site exhibited increased phosphorylation in response to glutamate overstimulation

From: Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

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  1. Prediction of the upstream kinase(s) targeting the identified neuronal proteins either activated or with at least one phosphosite exhibiting increased phosphorylation in response to glutamate treatment. Based upon the western blot data shown in Fig. 7 that revealed reduced phosphorylation of S21 of GSK3α, the phosphopeptide consisting of S21 derived from GSK3α is listed. For proteins such as Mapt (Tau) and Map1b containing multiple phosphorylation sites, the changes in phosphorylation states of other identified sites are presented. For NetworKIN prediction of upstream kinases, minimum score and maximum difference were set at 2 and 4, respectively
  2. The coloured letters highlight the identified phosphorylated amino acid residues
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