Fig. 3: Knockdown of NPTX2 expression inhibits the proliferation and liver metastasis of CRC in vivo. | Cell Death & Disease

Fig. 3: Knockdown of NPTX2 expression inhibits the proliferation and liver metastasis of CRC in vivo.

From: NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6

Fig. 3

a The proliferation of SW480 cells transfected with sh-NPTX2 or sh-control by subcutaneous tumor assay. b Comparison of subcutaneous tumor volume between sh-control group and sh-NPTX2 group (Student’s t test). c Comparison of subcutaneous tumor weight between sh-control group and sh-NPTX2 group (Student’s t test). d Expression of Ki-67 and PCNA in the subcutaneous tumor tissues (sh-control group [n = 5] and sh-NPTX2 group [n = 5]). e The proliferation of SW480 cells transfected with sh-NPTX2, sh-control, vector, and NPTX2-HA in an orthotopic mouse model of CRC (Student’s t test). f The proliferation of SW480 cells transfected with sh-NPTX2, sh-control, vector, and NPTX2-HA in a liver metastasis model of CRC (Student’s t test). All experiments had three replicates. Measurement data were presented as the mean ± SD. *P < 0.05

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