Fig. 5: NPTX2 directly interacts with FZD6 in CRC. | Cell Death & Disease

Fig. 5: NPTX2 directly interacts with FZD6 in CRC.

From: NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6

Fig. 5

a The mRNA expression of FZD6 in normal colon tissue, CRC, liver metastasis (LM) analyzed by GSE6988 dataset (Student’s t test). b The mRNA expression of NPTX2 in normal colon tissue, CRC, liver metastasis (LM) analyzed by GSE6988 dataset (Student’s t test). c, d Co-IP of NPTX2 with FZD6, a receptor of the Wnt/β-catenin pathway, in SW480 and LoVo cells; e Co-localization of NPTX2 with FZD6 in CRC tissues, as analyzed with immunofluorescence assay. All experiments had three replicates. Measurement data were presented as the mean ± SD. ***P < 0.0001

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