Fig. 6: Selectivity profile of GSK’074. | Cell Death & Disease

Fig. 6: Selectivity profile of GSK’074.

From: Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models

Fig. 6

Binding of GSK’074 (100 nM) against 468 human kinases (403 non-mutant kinases, 65 mutant kinases) was assessed by DiscoveRx KINOMEscan™. a Selectivity scores of GSK’074. Selectivity score was defined as the number of non-mutant kinases bound to GSK’074 <35% of control (S(35)), 10% of control (S(10)), or 1% of control (S(1)). b TREEspot map of kinases potentially targeted by GSK’074. Binding with RIP1 (0% of control) was shown by the blue circle, red circles indicated other kinases that displayed similar binding as RIP1 (S(1))

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