Fig. 4: SMAD5-AS1 inhibits proliferation in vivo. | Cell Death & Disease

Fig. 4: SMAD5-AS1 inhibits proliferation in vivo.

From: Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/β-catenin pathway by sponging miR-135b-5p to elevate expression of APC

Fig. 4

a The nude mice were injected with TMD8 cells transfected with SMAD5-AS1-overexpressed plasmid/control plasmid or shSMAD5-AS1 plasmid/control plasmid subcutaneously, which was shown in the upper panel. Tumors were removed after 1 month, which were indicated in the bottom panel. Tumor volume and tumor weight were analyzed in SMAD5-AS1-overexpressed/control group (b) and shSMAD5-AS1/control group (c). The transplanted tumor with the overexpression of SMAD5-AS1 had a smaller volume and lower weight and the transplanted tumor with the down-regulation of SMAD5-AS1 had a larger volume and higher weight. *P < 0.05

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