Fig. 8: SOX12 expression positively correlates with GLS, GOT2, ASNS, and HIF-1α expression in CRC. | Cell Death & Disease

Fig. 8: SOX12 expression positively correlates with GLS, GOT2, ASNS, and HIF-1α expression in CRC.

From: SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis

Fig. 8

a Representative images of IHC staining for SOX12, HIF-1α, GLS, GOT, and ASNS in human CRC tissues. b Analysis of correlations between SOX12 expression and GOT2 and ASNS expression in human CRC tissues. c Kaplan–Meier analysis of the associations between HIF-1α expression and the recurrence and overall survival of patients with CRC (upper panel). Kaplan–Meier analysis of the associations between concurrent SOX12 and HIF-1α expression and the recurrence and OS of patients with CRC (lower panel). d Kaplan–Meier analysis of the associations between GLS expression and the recurrence and OS of patients with CRC (upper panel). Kaplan–Meier analysis of the associations between simultaneous SOX12 and GLS expression and the relapse and OS of patients with CRC (lower panel). e Kaplan–Meier analysis of the associations between GOT2 expression and the relapse and OS of patients with CRC (upper panel). Kaplan–Meier analysis of the associations between simultaneous SOX12 and GOT2 expression and the relapse and OS of patients with CRC (lower panel). f Kaplan–Meier analysis of the associations between ASNS expression and the relapse and OS of patients with CRC (upper panel). Kaplan–Meier analysis of the associations between simultaneous SOX12 and ASNS expression and the relapse and OS of patients with CRC (lower panel)

Back to article page