Fig. 3: Small-molecule inhibitors of CDKs reduce iPSC generation as CDKIs. | Cell Death & Disease

Fig. 3: Small-molecule inhibitors of CDKs reduce iPSC generation as CDKIs.

From: Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability

Fig. 3

a, b Effects of CDK2 (a) and CDK4 (b) inhibitor treatment on efficiency of iPSC generation in WT, p21−/−, p27−/−, and p18−/− MEFs. Inhibitors were added in the medium during reprogramming. Data are representative of two or three independent experiments. Error bars, ± SD. *p < 0.05; **p < 0.01, ***p < 0.001 by two-tailed t test

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