Fig. 4: TUG1 positively regulates HIF-1α via miR-143-5p silencing. | Cell Death & Disease

Fig. 4: TUG1 positively regulates HIF-1α via miR-143-5p silencing.

From: Long non-coding RNA Taurine upregulated gene 1 promotes osteosarcoma cell metastasis by mediating HIF-1α via miR-143-5p

Fig. 4

a Sequence alignment of miR-143-5p and HIF-1α was shown. b miR-143-5p reduced the activity of the luciferase reporter with the HIF-1α wild-type 3′UTR but not the mutant 3′UTR. c, d TUG1 knockdown decreased HIF-1α expression, which was reversed by the miR-143-5p inhibitor for mRNA and protein levels. **P < 0.01; ***P < 0.001; ns, not significant. e, f TUG1 upregulation increased HIF-1α expression, which was reversed by the miR-143-5p mimics for mRNA and protein levels. **P < 0.01; ***P < 0.001; ns, not significant

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