Fig. 6: TUG1 positively regulates OS cell invasion and angiogenesis via miR-143-5p silencing. | Cell Death & Disease

Fig. 6: TUG1 positively regulates OS cell invasion and angiogenesis via miR-143-5p silencing.

From: Long non-coding RNA Taurine upregulated gene 1 promotes osteosarcoma cell metastasis by mediating HIF-1α via miR-143-5p

Fig. 6

a TUG1 knockdown inhibited OS cell invasion, which was reversed by the miR-143-5p inhibitor. Scale bar = 50 μm. b TUG1 knockdown inhibited HUVECs angiogenesis, which was reversed by the miR-143-5p inhibitor. Scale bar = 100 μm. c, d TUG1 knockdown inhibited OS cell proliferation, which was reversed by the miR-143-5p inhibitor. e, f TUG1 knockdown upregulated the protein level of epithelial marker E-cadherin; it decreased the expression of mesenchymal markers N-cadherin and vimentin, and also decreased Twist, but not Slug, expression, which was reversed by the miR-144-3p inhibitor. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant

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