Fig. 7: BBR alleviates IMQ-induced psoriasis-like skin lesion in the mouse model. | Cell Death & Disease

Fig. 7: BBR alleviates IMQ-induced psoriasis-like skin lesion in the mouse model.

From: Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes

Fig. 7

a Representative images of mice treated with vehicle (control), IMQ or IMQ together with BBR for 5 days. For each group, n = 4. b Analysis of the increase in ear thickness in different groups after treatment with vehicle, IMQ or IMQ together with BBR for 5 days. Each point represents one mouse. c, d Analysis of epidermal thickness of back (C) and ear (D) skin in different groups. e, f Representative histological sections of the back (E, bar = 200 μm) and ear (F, bar = 100 μm) skins of mice. g–i IHC staining of Ki67 (G), p-STAT3 (H), and CDC6 (I) in back skin of different groups, bar = 100 μm. j Schematic model of the mechanisms by which BBR downregulates CDC6 and inhibits proliferation in human keratinocytes. P, phosphate

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