Table 2 The known demethylation processes of transcription factors
| Â | Substrate | Enzyme | Tumor type | Transcription activity | References |
|---|---|---|---|---|---|
Demethylation | P53K370me2 | LSD1 | 293T, MCF7 (breast cancer cell), U2OS (Osteosarcoma cell) | Inhibition | |
| Â | P53K372me1 | KDM3A | Breast cancer | Inhibition | |
| Â | RelAK218me1, K221me2 | FBXL11 | 293C6, HT29 (colon cancer cell) | Inhibition | |
|  | ERαK266me1 | LSD1 | Breast cancer | Activation | |
| Â | YY2K247me1 | LSD1 | HeLa (cervical carcinoma) | Inhibition |
