Fig. 4: The function of CT55 in CAC depends on NF-κB signaling. | Cell Death & Disease

Fig. 4: The function of CT55 in CAC depends on NF-κB signaling.

From: Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-κB signaling

Fig. 4

a Schematic of the DSS-induced colitis used to identify the relevant pathway of Ct55 function in colitis-associated cancer (CAC). b Principal component analysis shows two distinct clusters for the WT and Ct55 KO samples (WT n = 2, Ct55 KO n = 3). c A column diagram shows the differentially expressed genes between WT and Ct55 KO groups. Gene sets with a fold change >2 and false discovery rate (FDR) < 0.05 were considered statistically significant. d Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the most significantly enriched pathways (P < 0.05 by Fisher’s exact test) on the basis of the identified differentially expressed genes between the WT and Ct55 KO groups. e Gene set enrichment analysis (GSEA) of the NF-κB signaling pathway in the WT and Ct55 KO groups. f Western blot analysis of the indicated protein levels in tumor tissues of the WT and Ct55 KO mice. β-Actin served as the loading control

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