Fig. 2: TdGSH prevents LOsG administration-induced alterations of ROS homeostasis.
From: Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure
WBC ROS measurements (a–d) were performed at before zero hour (0 h) and one hour (1 h) after gavage of glucose (2 g/kg body weight) on P38. a–c Representative examples of flow cytometric analysis of WBC ROS in 3 groups. d Quantification of WBC ROS (***p < 0.001 LOsG versus sham; ††p < 0.01 LOsG versus LOsG.GSH). Examples of e–g islet and i–k acinar cell ROS staining in three groups (n = 6/group). h, l Quantification of ROS-reactive stains (red, presented as arbitrary unit/mm2) in islet and acinar tissue, respectively. Data are shown as mean ± SEM (n = 6–10; ***p < 0.001 represents both LOsG versus sham or LOsG.TdGSH). White photo bar is 50 μm
