Fig. 5: TdGSH prevents LOsG-induced alterations of FoxO1, TXNIP, and MafA expressions.
From: Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure
a–c Examples of islet FoxO1 staining (green) in sham, LOsG, and LOsG.TdGSH groups (n = 6/group); d FoxO1 mRNA quantification from the same pancreatic tissues. e Quantification of pancreatic FoxO1 by western blot (n = 4/group, ***p < 0.001). f–h Examples of islet TXNIP staining; i Quantification of β-cell nuclear TXNIP immunoreactivities (green, n = 96–100 β-cells/group, plotted as percentage of sham group). j–l Examples of islet MafA expression; m Quantification of MafA immunoreactivities (green, n = 90–93 β-cells/group, plotted as AU/ 10 μm2). ND, not detectable. Data are shown as mean ± SEM. ***p < 0.001 represents both LOsG versus sham or LOsG.TdGSH. NS, not significant. White photo bar is 50 μm
