Fig. 1: The expression of Fascin actin-bundling protein 1 (FSCN1) in tongue squamous cell carcinoma (TSCC) | Cell Death & Disease

Fig. 1: The expression of Fascin actin-bundling protein 1 (FSCN1) in tongue squamous cell carcinoma (TSCC)

From: FSCN1 is an effective marker of poor prognosis and a potential therapeutic target in human tongue squamous cell carcinoma

Fig. 1

a Comparison of all of the genes over-expressed in tongue squamous cell carcinoma vs. normal tissues in the Estilo study. b Relative FSCN1 expression in tongue squamous cell carcinoma vs. normal tissues in the Talbot, Estilo, Ye, and Kuriakose databases. FSCN1 is overexpressed in human TSCC tissues (T) compared to the adjacent normal tissues (N) in TSCC microarray data sets available from Oncomine. c Immunoblotting analysis of FSCN1 protein levels in five TSCC cell lines and normal tongue tissue. d Immunoblotting evaluates the knockdown efficiency of FSCN1 with two unique shRNAs (#1, #2) in CAL-27 and SCC-25 cells. Normal: normal tongue tissue; Scramble (sc): the lentiviral vector with a scrambled sequence that does not target any mRNA. β-Actin was included as a loading control. All statistical analyses were performed using Student paired t test. All statistical tests were two-sided. Data is presented as mean ± S.D. **p < 0.01 vs. the corresponding control groups

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