Fig. 6: ASK retards tumor growth and precludes primary tumor relapse in an MDA-MB-231 subcutaneous xenograft assay. | Cell Death & Disease

Fig. 6: ASK retards tumor growth and precludes primary tumor relapse in an MDA-MB-231 subcutaneous xenograft assay.

From: Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors

Fig. 6

a Eleven Balb/c NOD/SCID mice were inoculated subcutaneously with 2.5 × 106 cells and were then injected ip, in a blinded fashion, with ASO-C (six mice) or Andes-1537 (five mice) on days 12, 14, 16, 19, 21, 23, and 26 post-cell inoculation. Tumor size was monitored and the experiment was terminated on day 27. One mouse from the ASO-C group was sacrificed on day 23 for having reached the ethical limit for tumor size (#). **p < 0.005, two-tailed Student’s t-test, ASO-C vs. Andes 1537, day 27. b Fifteen mice were inoculated as in a and injected ip with ASO-C (five mice) or Andes-1537 (10 mice) on days 21, 23, 26, 30, 33, 35, 37, 40, 42, and 44 post-cell inoculation. Primary tumors were surgically resected on day 29. The experiment was terminated on day 51. **p < 0.005, ****p < 0.0001, two-tailed Student’s t-test, ASO-C vs. Andes-1537, day 51. Graphs represent Mean ± S.E.M.

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