Fig. 2: Upregulation of TC2N inhibits BC cell proliferation in vitro and tumor growth in vivo.
From: Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer
a TCGA BC RNA-seq dataset identified the top 10 categories of the GO biological processes that associate with TC2N expression. b MCF7 and MDA-MB-231 cells with TC2N or vector stable transfection were identified by WB. c The viability of stable transfected MCF7 and MDA-MB-231 cells were measured by MTS assays. d The proliferation of stable transfected MCF7 and MDA-MB-231 cells were measured by colony formation assays. e MCF7-TC2N and MDA-MB-231-TC2N cells with NC or shRNA stable transfection were identified by WB. f The viability of stable transfected MCF7-TC2N and MDA-MB-231-TC2N cells were measured by MTS assays. g The proliferation of stable transfected MCF7-TC2N and MDA-MB-231-TC2N cells were measured by colony formation assays. h Photograph of the tumor removed from nude mice at 28 days after inoculated with stable transfected MDA-MB-231 cells. i Tumor volume of mice was calculated every 3-5 days. j Tumor weights from nude mice were measured. *P < 0.05; **P < 0.01
