Fig. 7: Enhancer of zeste homolog 2 (EZH2) inhibited microRNA-708 (miR-708) expression. | Cell Death & Disease

Fig. 7: Enhancer of zeste homolog 2 (EZH2) inhibited microRNA-708 (miR-708) expression.

From: Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/β-catenin pathway in glioma

Fig. 7

a The methylation status of the miR-708 promoter was detected in normal brain cell line and glioma cell lines. b Histone H3 lysine 27 trimethylation (H3K27me3) was enriched around the miR-708 promoter region. c EZH2 down-regulation increased miR-708 expression in LN382 and GBM-GY cell lines. d Treated with deazaneplanocin A (DZNep) elevated miR-708 expression in LN382 and GBM-GY cell lines

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