Fig. 2: Knockdown of ZNF384 by shRNA inhibits the proliferation of hepatocellular carcinoma cells. | Cell Death & Disease

Fig. 2: Knockdown of ZNF384 by shRNA inhibits the proliferation of hepatocellular carcinoma cells.

From: Overexpression of zinc finger protein 384 (ZNF 384), a poor prognostic predictor, promotes cell growth by upregulating the expression of Cyclin D1 in Hepatocellular carcinoma

Fig. 2

a Western blot analysis of ZNF384 expression in HCCLM3 and PLC/PRF/5 cells treated with shRNA targeting ZNF384. Silencing ZNF384 in HCCLM3 and PLC/PRF/5 cells effectively inhibits cell growth (b) clone formation (c). Knockdown of ZNF384 in HCCLM3 and PLC/PRF/5 cell effectively inhibits G1/S phase transition in EdU immunofluorescence staining (d) and Flow cytometry analysis (e, f). All results are expressed as the mean ± SD of three independent experiments (*0.01 ≤ P < 0.05; **0.001 ≤ P < 0.01, ***P < 0.001)

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