Fig. 6: miR-18a and miR-19a reverse the inhibitory effect of IRF-1. | Cell Death & Disease

Fig. 6: miR-18a and miR-19a reverse the inhibitory effect of IRF-1.

From: MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling

Fig. 6

a After 48 hours of Dox induction, the expression levels of IRF-1, β-catenin, C-Myc and Axin2 in MKN45/Lv-IRF-1 and AGS/Lv-IRF-1 cells treated with a mimic mixture and an NC mimic compared with those in MKN45 and AGS cell lines transfected with Lv-IRF-1 and Lv-Null, respectively, were analysed by western blotting. b Wound-healing assay and c migration assay of MKN45/Lv-IRF-1 and AGS/Lv-IRF-1 cells treated with an NC mimic, a miR-18a mimic, a miR-19a mimic and a mimic mixture. All the above experiments were independently performed in triplicate (N = 3). *P < 0.05, as determined by paired Student’s t test. The data in b and c are presented as the means ± SDs

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