Fig. 3: Transcriptome analysis of mouse podocytes treated with rFGF1ΔHBS or rFGF1WT and challenged with HG. | Cell Death & Disease

Fig. 3: Transcriptome analysis of mouse podocytes treated with rFGF1ΔHBS or rFGF1WT and challenged with HG.

From: FGF1ΔHBS ameliorates chronic kidney disease via PI3K/AKT mediated suppression of oxidative stress and inflammation

Fig. 3

Mouse podocytes were pretreated with rFGF1WT (100 ng/mL) or rFGF1ΔHBS (100 ng/mL) for 1 h, followed by treatment with HG (25 mM) for an additional 12 h. a Hierarchical clustering of differentially expressed genes. Red represents increased expression, while blue indicates decreased expression. The Z score was chosen to display the fragments per kilobase of exon per million reads mapped (FPKM) values of differentially expressed genes. b FPKM values of selected inflammatory genes. c Real-time PCR analysis of Lbp, Cxcl12, Il17rb, and Il33 mRNA expression. d FPKM values of selected genes related to oxidative stress. e Real-time PCR analysis of Nfe2l2, Nqo1, Cat1, and Sod2 mRNA expression

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