Fig. 4: FOXP4 was positively regulated by FOXP4-AS1 and exerted oncogenic property in PCa. | Cell Death & Disease

Fig. 4: FOXP4 was positively regulated by FOXP4-AS1 and exerted oncogenic property in PCa.

From: LncRNA FOXP4-AS1 is activated by PAX5 and promotes the growth of prostate cancer by sequestering miR-3184-5p to upregulate FOXP4

Fig. 4

a UCSC data revealed that FOXP4 is a nearby gene of FOXP4-AS1. b The mRNA and protein level of FOXP4 in cells transfected with pcDNA-FOXP4-AS1 or sh-FOXP4-AS1 were measured by qRT-PCR and western blotting. c Upregulation of FOXP4 in PCa samples. d Positive expression association between FOXP4-AS1 and FOXP4 in PCa samples was analyzed by Pearson correlation analysis. e Kaplan–Meier analysis of patients with PCa with high or low expression level of FOXP4. f Relative high level of FOXP4 was detected in PCa cells and one normal control cell. g Cell viability was examined in response to the overexpression or knockdown of FOXP4 by the CCK-8 assay. h Caspase-3 activity was increased in LNCaP cell transfected with FOXP4 expression vector but was increased in PC-3 cell transfected with sh-FOXP4#1. **P < 0.01

Back to article page