Fig. 5: SNHG14 stabilized EZH2 mRNA by interacting with FUS. | Cell Death & Disease

Fig. 5: SNHG14 stabilized EZH2 mRNA by interacting with FUS.

From: Long noncoding RNA SNHG14 facilitates colorectal cancer metastasis through targeting EZH2-regulated EPHA7

Fig. 5

a, b The effect of SNHG14 on EZH2 expression in indicated CRC cells was detected by qRT-PCR and western blot analysis. c Luciferase reporter assay was conducted to assess the influence of SNHG14 on EZH2 transcription. d RIP assay validated the common interaction of FUS with both SNHG14 and EZH2 mRNA. e The impact of SNHG14 on FUS-interacted EZH2 mRNA was estimated by preforming RIP assay. f qRT-PCR result of EZH2 level in indicated CRC cells. g The degradation rate of EZH2 mRNA in indicated CRC cells under the treatment of actinomycin D was tested by qRT-PCR. *P < 0.05, **P < 0.01

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