Fig. 7: LZ-101 has a potential anti-tumor effect and low toxicity in vivo. | Cell Death & Disease

Fig. 7: LZ-101 has a potential anti-tumor effect and low toxicity in vivo.

From: LZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells

Fig. 7

a Tumor volumes of control, 5-fluorouracil, LZ-101 treatment groups were measured and calculated every 3 days. b Weight of tumor in control, 5-fluorouracil, LZ-101 treatment groups. *P < 0.05, **P < 0.01 compared with control group. c DNA damage and FOXO3a, Bim, Bcl-2, Bax expression detected by TUNEL assay and immunohistochemistry in tumor xenograft tissues. Scale bars, 50 µm. d Nude mice weight was recorded every 3 days. e H&E stained main organs of mice from treated and control sets to evaluate the toxicity of LZ-101. Scale bars, 50 µm

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