Fig. 8: The effects of sterols on the DMBA-induced mammary carcinoma in rats. | Cell Death & Disease

Fig. 8: The effects of sterols on the DMBA-induced mammary carcinoma in rats.

From: The beneficial androgenic action of steroidal aromatase inactivators in estrogen-dependent breast cancer after failure of nonsteroidal drugs

Fig. 8

At an age of 50–54 days, female Sprague-Dawley rats were dosed intragastrically with 20 mg DMBA. when at least one tumor measuring 1 cm in diameter was found, the rats were ovariectomized and given intramuscular 1 μg/rat E2 daily. Animals were selected for experiments when at least one tumor per rat had reached a diameter of 1.5 cm. The skin covering the tumor was shaved and animals were divided into four groups. The tumors were treated by direct application of DHT, 4-OHT, and 17-HEXE. Untreated tumors served as controls. a Representative images of the tumors. b Tumor growth curve. c Average number of tumor nodules before and after treatment.The data represent six sets of independent experiments and are shown as the means ± SD. *P < 0.05, **P ≤ 0.01 vs. control group

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