Fig. 2: Role of IL-32γ on the tumor growth and tumor metastasis of lung cancer stem cells.
From: IL-32γ suppresses lung cancer stem cell growth via inhibition of ITGAV-mediated STAT5 pathway
a Tumor growth inhibition (as assessed by tumor volume) in B16F10 bearing IL-32γ Tg mice. Tumor growth (left panel) from mice injected with CD133- B16F10 cells or CD133+ B16F10 cells is shown. Tumor volume (middle panel) and tumor weight (right panel) are shown in a. n = 8, *p < 0.05; ***p < 0.001. b Overexpression of IL-32γ inhibits the tumor growth of lung cancer stem cells in xenografts. Tumors from mice injected with control vector- or IL-32γ-CD133+ A549 cells are shown. Tumor volume (middle panel) and tumor weight (right panel) are shown in b. n = 8, *p < 0.05. c Overexpression of IL-32γ inhibits the metastasis of lung CSCs in xenografts. Metastasized tumor nodules from mice injected with control vector- or IL-32γ-CD133+ A549 cells are shown. Tumor nodules were measured after the mice were killed. n = 6, ***p < 0.001
