Fig. 3: Overexpression of CTRP3 inhibited cardiomyocyte apoptosis, regulated the cellular profile, and enhanced MSCs survival and retention. | Cell Death & Disease

Fig. 3: Overexpression of CTRP3 inhibited cardiomyocyte apoptosis, regulated the cellular profile, and enhanced MSCs survival and retention.

From: C1q/tumor necrosis factor-related protein-3-engineered mesenchymal stromal cells attenuate cardiac impairment in mice with myocardial infarction

Fig. 3

a–c Representative confocal microscopic images of vWF (a), αSMA (b), and vimentin-positive cells (c) (red) in the infarct border region 4 weeks after cell injection. Nuclei were stained with DAPI (blue). Quantification of capillary density (d), arteriole density (e), and fibroblasts (f), summarized in bar graphs (n = 5). g, h Representative photographs and quantified analysis of TUNEL-labeled (green) apoptotic cardiomyocytes at 28 days after MI (n = 4). i Representative images of MSCs in hearts 7 days after MI. j Quantification of MSCs in the peri-infarct area, as determined by the ratio of the GFP-positive cells (MSCs) per 1000 nuclei (n = 5). k Engraftment curves of implanted MSCs were compared at the indicated times (n = 5). All data are expressed as means ± SEMs. *P < 0.05; **P < 0.01; ***P < 0.001

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