Fig. 6: CTRP3 treatment resulted in upregulation of SOD2 and MT1/2 expression levels and increased MMP9 secretion in MSCs. | Cell Death & Disease

Fig. 6: CTRP3 treatment resulted in upregulation of SOD2 and MT1/2 expression levels and increased MMP9 secretion in MSCs.

From: C1q/tumor necrosis factor-related protein-3-engineered mesenchymal stromal cells attenuate cardiac impairment in mice with myocardial infarction

Fig. 6

a A heat map illustrating the levels of 70 mRNAs related to MSCs biological functions in the CTRP3 and vehicle group (n = 4). b mRNA and (c and d) protein expression levels of genes from (a) were analyzed by RT-PCR (n = 4) and western blotting (n = 6–10). The gene and protein expression levels were normalized to that of β-actin. e, f Representative images of in-gel zymography for analysis of MMPs activity in CM from MSCs (gray and reversed-phase). MMP9 activity was quantified by densitometric analysis (n = 4). All data are presented as means ± SEMs. *P < 0.05; **P < 0.01; ***P < 0.001. ns, not significant

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