Fig. 1: Heterogeneous sensitivities for VEN in BCP-ALL.
From: Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling
Cell death induction (flow cytometry, forward/side scatter criteria) upon exposure of a BCP-ALL cell lines (N = 6, 72 h; from left [low EC50, sensitive] to right [high EC50, insensitive]: RS4;11, KOPN-8, UoCB6, REH, RCH-ACV, and Nalm-6), b patient-derived BCP-ALL xenograft samples (N = 27, 24 h, from left [low EC50, sensitive] to right [high EC50, insensitive]: PDX1, PDX2, …, PDX27) or peripheral blood mononuclear cells from healthy donors (N = 3, dashed lines) to increasing concentrations of VEN (0.1, 1, 10, 50, 100, 250, 500 nM, 1, 3, 5, and 10 µM) showing heterogeneous half maximal effective concentrations (EC50) indicating variable VEN sensitivities of BCP-ALL. (See also Supplementary Tables 1 and 2)
