Fig. 8: Schematic illustrating the pathogenesis underlying the disease phenotype of MLP-deficiency in MLP KO hESC-CMs. | Cell Death & Disease

Fig. 8: Schematic illustrating the pathogenesis underlying the disease phenotype of MLP-deficiency in MLP KO hESC-CMs.

From: MLP-deficient human pluripotent stem cell derived cardiomyocytes develop hypertrophic cardiomyopathy and heart failure phenotypes due to abnormal calcium handling

Fig. 8

Abnormal calcium handling and elevation of cytoplasmic Ca2+ concentrations are the central mechanism for pathogenesis of HCM and HF in MLP KO hESC-CMs. LTCC, L-type calcium channels; NCX, sodium-calcium exchange pump; CaM, Calmodulin; CnA, calcineurin

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