Fig. 6: Betulin synergizes Sorafenib’s effect on HCC in situ growth in the mouse liver. | Cell Death & Disease

Fig. 6: Betulin synergizes Sorafenib’s effect on HCC in situ growth in the mouse liver.

From: SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity

Fig. 6

a The in situ xenograft tumors were established by injected MHCC97-H cells directly into mouse livers. Tumor-bearing mice then received vehicle control, or the indicated concentrations of Sorafenib, or 2 mg/kg Betulin or the indicated concentration of Sorafenib + 2 mg/kg Betulin orally every other day 10 times. At day 21 post treatment, mice were scanned by in vivo small-animal MicroPET imaging (N = 10). The images show the in situ tumors. b The 18F-FDG intensity analysis and quantification results. c Relative inhibitory rate of tumor growth calculated from (b). d Livers from control or tumor-bearing mice from a. e Representative tumor nodules from each treatment group. f Quantification results from e

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