Fig. 7

a A schematic diagram highlighting PML regulation in breast cancer: (i) Negative correlation between ERα –PML and ERα-CK2α mediated PML degradation in ERα⁺ BCa and (ii) Positive correlation between ERβ-PML and the hypothesis regarding the possibility of ERβ mediated PML gene regulation towards stabilization of PML in ERα⁻ BCa. b Model: ERβ follows estrogen signaling, tethering to ERE/AP-1 sites on PML promoter leading to its transcriptional upregulation that allows the formation and stabilization of PML-NBs. PML upregulation leads to subsequent reduction in Survivin and stabilization of Foxo3a and its target genes p21 and p27 and the consequent effect in controlling breast carcinogenesis