Fig. 2: Pharmacological Inhibition of CtBP1/CtBP2 heterodimer formation by CtBP inhibitors.
From: Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein
a CtBP1-YFP and CtBP2-CFP heterodimerization was measured by fluorescence resonance energy transfer (FRET) acceptor photobleaching (see Materials and methods). b Inhibition of CtBP dimerization FRET signal by the CtBP inhibitors CI19, CI22, CI23, and CI24 at 10 μM concentrations. c Dose-response curve of inhibition of CtBP dimerization FRET signal by increased concentrations of CI24 CtBP inhibitor. The error bars represent the s.d. of the mean from at least two independent experiments. *Indicates P < 0.05 and **indicates P < 0.01. Error bars in c are smaller than the size of the symbols
