Fig. 3: Schematic of 130 plasma samples and therapeutic response from 55 patients. | Cell Death & Disease

Fig. 3: Schematic of 130 plasma samples and therapeutic response from 55 patients.

From: Chromosomal instability of circulating tumor DNA reflect therapeutic responses in advanced gastric cancer

Fig. 3

For patients with pretherapeutic chromosomal instability, the response rate (59%, 16/27) was significantly higher than that in patients with chromosomal stability (32%, 9/28) (P = 0.043). The cutoff value of chromosomal instability was defined as the mean + SD of the CNI scores (56.60) in cfDNA from 100 healthy people. CNI scores also fluctuated during drug treatment among 26 patients with dynamic plasmas. CNI scores copy number instability score, CIN chromosomal instability, CNS chromosomal stability, PR partial response, SD stable disease, PD progressive disease

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