Fig. 3: ER stress responses in PRSS1 transgenic mice treated with caerulein.
From: ATF6 regulates the development of chronic pancreatitis by inducing p53-mediated apoptosis
a Morphological changes in the endoplasmic reticulum (ER) in response to caerulein treatment in PRSS1 transgenic mice were determined by transmission electron microscopy. Red arrows (↑): endoplasmic reticulum; yellow arrows (↑): zymogen granule; blue arrows (↑): cell nucleus. ATF6, XBP1, and CHOP gene (b) and protein (c) levels in pancreatic tissues, as determined by quantitative RT-PCR and western blotting, respectively. ATF6 activating transcription factor 6, XBP1 X-box-binding protein 1, CHOP C/EBP-homologous protein, GAPDH glyceraldehyde-3-phosphate dehydrogenase, ns no significant difference, WT wild-type, BL baseline, W weeks, ns no significant difference; *P < 0.05 and **P < 0.01
