Fig. 4: Acinar apoptosis and p53 expression in CP.
From: ATF6 regulates the development of chronic pancreatitis by inducing p53-mediated apoptosis
a Transferase-mediated d-UTP nick-end-labelling (TUNEL) assay in PRSS1 transgenic mice treated with caerulein for 1, 2, and 4 weeks. b p53 mRNA levels in pancreatic tissues from PRSS1 transgenic mice treated with caerulein to induce chronic pancreatitis (CP). Mice were sacrificed 1, 2, and 4 weeks after treatment, and the mRNA levels were determined by quantitative RT-PCR. p53 protein levels in pancreatic tissues from PRSS1 transgenic mice treated with caerulein by Western blotting (c) and immunohistochemistry (IHC) (d). e Haematoxylin and eosin (h, e) and p53 IHC in CP patients and healthy volunteers. BL baseline, W weeks; *P < 0.05
