Fig. 6: Regulation of p53 expression and CP progression by ATF6 in PRSS1 acinar cells.
From: ATF6 regulates the development of chronic pancreatitis by inducing p53-mediated apoptosis
The expression levels of ATF6 and p53 in response to lipopolysaccharide (LPS) induction in primary acinar cells isolated from PRSS1 transgenic mice were determined by quantitative RT-PCR (a) and western blotting (b). ATF6 expression (c), inflammatory factors (d), and cell apoptosis (e) measured by quantitative RT-PCR, ELISA, and transferase-mediated d-UTP nick-end-labelling (TUNEL) assays, respectively. f Expression of ATF6 and p53 in LPS-induced ATF6-suppressed cells. shATF6 shATF6 virus, CON control group, ATF6 activating transcription factor 6, ns no significant difference; *P < 0.05 and **P < 0.01
