Fig. 2: Skeletal phenotypes and bone microstructure of miR-29aTg/OCN mice. | Cell Death & Disease

Fig. 2: Skeletal phenotypes and bone microstructure of miR-29aTg/OCN mice.

From: MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12

Fig. 2

Increased miR-29a expression solely occurred in bone tissue in miR-29aTg/OCN mice (a). Macroscopic morphology of 7-day-old miR-29aTg/OCN mice was similar to wild-type mice (b); scale bar: 20 mm. Increased serum osteocalcin and reduced TRAP5b levels (c) and strong PCNA immunostaining (d) in osteoblasts in miR-29aTg/OCN mice; scale bar: 30 μm (low magnification); 10 μm (high magnification). Increased fluorescent calcein accumulation and MAR along with femur length in 8-week-old miR-29aTg/OCN mice (e); scale bar: 30 μm. Significant increases in cortical BMD and Ct.Th (f), trabecular BMD and BV/TV (g) together with spinal BMD and BV/TV (h) in miR-29aTg/OCN mice; scale bar: 5 mm. The data are expressed mean ± SEM calculated from six mice. Asterisks * indicate significant difference from wild-type mice

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