Fig. 6: Osteoclast-formation capacity of bone marrow macrophages in miR-29aTg/OCN mice. | Cell Death & Disease

Fig. 6: Osteoclast-formation capacity of bone marrow macrophages in miR-29aTg/OCN mice.

From: MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12

Fig. 6

Schematic drawing of bone marrow macrophages co-incubated with bone marrow mesenchymal stem cells (a). Decreased osteoclast differentiation (scale bar: 8 μm) and pit formation (scale bar: 20 μm) of wild-type bone marrow macrophage and increased mineralized matrix formation (scale bar: 40 μm) of wild-type bone marrow cells co-incubated with miR-29aTg/OCN bone marrow mesenchymal cells (b, c). Investigations are expressed mean ± SEM calculated from six mice. High CD14 + macrophages (d) rather than CD11 + CD115 + monocytes (e) existed in bone marrow in miR-29aTg/OCN mice. Investigations are expressed mean ± SEM calculated from four mice. Asterisks * indicate significant difference from wild-type mice

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