Fig. 8: Schematic drawing of miR-29a signaling in osteoblasts repressed osteoclastic activity and osteoporosis. | Cell Death & Disease

Fig. 8: Schematic drawing of miR-29a signaling in osteoblasts repressed osteoclastic activity and osteoporosis.

From: MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12

Fig. 8

miR-29a targets RANKL expression and downregulates PCAF signaling-mediated CXCL12 expression to reduced osteoclastic activity, sustaining bone mass (a). Estrogen loss decreases miR-29a loss, which augments RANKL and CXCL12 expression in osteogenic cells, accelerating osteoclast formation and osteoporosis development (b)

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