Fig. 7: P. copri exacerbates carboplatin-associated inflammatory damage.
From: Prevotella copri is associated with carboplatin-induced gut toxicity
a Experimental setting. b Changes in P. copri. Mice were treated with or without metronidazole for 5 days and then colonised with P. copri and treated with carboplatin on day 0. The relative abundance of P. copri in the intestine was detected by real-time PCR. c Body weight changes of the mice during the experiment. d H&E staining of ileum and colon tissues (magnification, ×200). e Villus length of the ileum tissues. f Histological mucositis scores of the small intestine and colon. g Expression levels of IFN-γ, IL-1β, IL-6 and MCP-1 in ileum tissues of mice. h Expression levels of claudin-1, occludin and ZO-1 in ileum tissues of mice. Data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. Con Control; Car carboplatin; Met metronidazole
