Fig. 1: Effects of LT on patients.

a Changes in patients’ Cr and BUN, at different reperfusion time points after LT. n = 38 (patients with AKI after LT), *P < 0.05 vs patient baseline before LT; #P < 0.05 vs 3 days after reperfusion. b Changes in patients’ MAP during operation. n = 38 (patients with AKI after LT), *P < 0.05 vs patient baseline before LT; #P < 0.05 vs vascular clamped. c Changes in patients’ LPS at different reperfusion time points after LT. n = 38 (patients with AKI after LT), *P < 0.05 vs patient baseline before LT. d Donor liver damage of patients after LT (H&E staining; original magnification ×200) and pathological scores. e–g The level of Cx43 mRNA (qPCR) and Cx43 expression alternation after LT (immunohistochemical staining and western blotting; original magnification ×200). Tissues of donor liver were obtained from eight patients before or after reperfusion during the trimming phase, and normal liver tissues were obtained from eight patients with hepatic hemangioma